Drug Standards
Sigma Aldrich Fine Chemicals Biosciences Piroctone olamine United States Pharmacopeia (USP) Reference Standard | 68890-66-4 | MFCD01690792 | 200MG
Piroctone olamine United States Pharmacopeia (USP) Reference Standard | Mol Wt: 298.42 | 68890-66-4 | MFCD01690792 | 200MG
Medchemexpress LLC Beclomethasone 17-propionate | 5534-18-9 | 99.5% | 464.98 | 1 ML
Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and acts as a glucocorticoid receptor (GR) agonist. It demonstrates a higher affinity for GR compared to Beclomethasone dipropionate and is effective in suppressing cytokine production in lung macrophages of individuals with chronic obstructive pulmonary disease (COPD).
- Metabolism of beclomethasone dipropionate to 17-BMP is a crucial activation step.
- Inhibits LPS-stimulated CXCL8, TNFα, and IL-6.
- Upregulates GR-dependent genes FKBP51 and GILZ.
Medchemexpress LLC Lidocaine (Standard) | 137-58-6 | 100.0% | 50 MG
Lidocaine (Standard) is the analytical standard of Lidocaine, intended for research and analytical applications. It inhibits sodium channels involving complex voltage and using dependence, and decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. It is an amide derivative and has potential for the research of ventricular arrhythmia.
- Analytical standard for research and analytical applications
- Inhibits sodium channels
- Decreases growth, migration, and invasion of gastric carcinoma cells
- Potential for research of ventricular arrhythmia
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Apexbio Technology LLC Cefpodoxime Proxetil 87239-81-4 25mg
Cefpodoxime Proxetil is an oral prodrug belonging to the third-generation cephalosporin antibiotics After absorption it undergoes enzymatic hydrolysis in vivo converting to the active metabolite cefpodoxime Cefpodoxime exerts antibacterial activity by binding bacterial penicillin-binding proteins (PBPs) and inhibiting peptidoglycan synthesis thus preventing proper cell wall formation and ultimately leading to bacterial growth inhibition Cefpodoxime Proxetil is routinely employed in biomedical research studies to evaluate its antibacterial spectrum pharmacokinetics bioavailability and bacterial resistance mechanisms Additionally researchers utilize this compound for investigating antibacterial potential via in vitro and in vivo experiments with typical IC50 values varying based on bacterial strains and experimental conditions
Medchemexpress LLC Mogroside I A1 | 88901-46-6 | 1 MG
Mogroside I A1 is a triterpenoid glycoside and a nonsugar sweetener. It is known for being sweeter than sucrose and exhibits antioxidant, antidiabetic, and anticancer activities.
- Triterpenoid glycoside
- Nonsugar sweetener, sweeter than sucrose
- Exhibits antioxidant, antidiabetic, and anticancer activities
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
Apexbio Technology LLC Ruxolitinib (INCB018424) 941678-49-5 25mg
Ruxolitinib (INCB018424 CAS 941678-49-5) is a small-molecule inhibitor targeting Janus kinases JAK1 and JAK2 Structurally categorized as a cyclopentylpropionitrile derivative it functions via ATP-competitive inhibition of JAK1 and JAK2 kinase activities thereby suppressing downstream phosphorylation events involving STAT5 and ERK1/2 By impairing these signaling pathways ruxolitinib can reduce cellular proliferation It is widely researched in oncology particularly in studies analyzing its therapeutic potential in myeloproliferative disorders including myelofibrosis and conditions involving oncogenic JAK2 fusion proteins
Apexbio Technology LLC Felodipine 72509-76-3 10mM (in 1mL DMSO)
Felodipine (CAS 72509-76-3) is a dihydropyridine derivative that acts as a selective inhibitor of L-type calcium channels It binds selectively to L-type voltage-gated Ca channels and inhibits calcium influx displaying an IC50 of approximately 0 15 nM In biomedical research Felodipine is predominantly used to study calcium channel-mediated cellular processes including vascular smooth muscle contraction cardiovascular physiology and calcium signaling pathways
Apexbio Technology LLC Boceprevir 394730-60-0 25mg
Boceprevir is an oral inhibitor targeting hepatitis C virus (HCV) NS3 protease an enzyme essential for processing viral polyproteins during HCV replication The compound binds directly and reversibly to the NS3 enzyme s active site forming a covalent adduct through its ketoamide functionality Cell-based replicon assays demonstrated that boceprevir inhibits HCV replication in cultured hepatocytes with an IC90 of approximately 350 nM In preclinical studies boceprevir exhibited favorable selectivity towards HCV NS3 relative to human neutrophil elastase Commonly boceprevir is used in research investigating HCV replication mechanisms and NS3 enzyme function as well as in antiviral combination assays involving interferon-based regimens
Apexbio Technology LLC Voriconazole 137234-62-9 100mg
Voriconazole is a triazole antifungal agent functioning through the inhibition of lanosterol 14 -demethylase (CYP51) a cytochrome P450 enzyme responsible for fungal cell membrane ergosterol biosynthesis Voriconazole exhibits inhibitory activity at an IC50 of approximately 53 nM Its antifungal spectrum covers various fungal species including Candida species Aspergillus species Cryptococcus neoformans Trichosporon beigelii and Saccharomyces cerevisiae Due to these properties Voriconazole is frequently utilized in biomedical and pharmacological research involving fungal pathogenesis antifungal susceptibility studies and sterol biosynthesis pathway elucidation assays
Apexbio Technology LLC Tofacitinib (CP-690550,Tasocitinib) 477600-75-2 10mM (in 1mL DMSO)
Tofacitinib (CP-690550 Tasocitinib CAS 477600-75-2) is an orally bioavailable Janus kinase (JAK) inhibitor employed as a targeted immunomodulator The compound preferentially inhibits signaling mediated by JAK1 and JAK3 heterodimers displaying functional selectivity and less pronounced effects on JAK2 pathways Such inhibition disrupts downstream cytokine signaling notably IL-2 IL-4 IL-7 IL-9 IL-15 and IL-21 cytokines implicated in lymphocyte activation proliferation and differentiation Recent studies also indicate suppression of STAT signaling and potential modulation of additional kinase targets Tofacitinib is broadly studied in autoimmune research especially in rheumatoid arthritis and ulcerative colitis models
Apexbio Technology LLC Minocycline HCl(Synonyms: Minocycline hydrochloride, Minocin, Dynacin, Solodyn, Minomycin, Akamin, Arestin, Minostad), 100mg, CAS: 13614-98-7.
Minocycline HCl (CAS 13614-98-7) is a semisynthetic tetracycline derivative known for its broad-spectrum antimicrobial properties and biological activity beyond antibacterial effects It acts primarily by inhibiting bacterial protein synthesis through reversible binding to the 30S ribosomal subunit thus preventing aminoacyl-tRNA from attaching to the ribosome-mRNA complex Independent of its antibiotic activity minocycline exhibits anti-inflammatory neuroprotective and antiapoptotic effects potentially mediated by suppression of cellular inflammatory pathways reduction of microglial activation and modulation of apoptotic signaling These properties make minocycline a compound of considerable interest in preclinical research for studying inflammation-related pathologies and neurodegenerative disorders
Apexbio Technology LLC Isradipine (Dynacirc)(Synonyms: Dynacirc, Prescal, Lomir, PN 200-110, Isrodipine, (+/-)-Isradipine, Isradipex), 50mg, CAS: 75695-93-1.
Isradipine (Dynacirc CAS 75695-93-1) is a small molecule antagonist belonging to the dihydropyridine class of calcium channel blockers It functions primarily by inhibiting L-type voltage-gated calcium channels thereby decreasing intracellular calcium influx into cardiac and vascular smooth muscle cells This inhibitory effect relaxes vascular smooth muscle tissue leading to vasodilation and subsequent reduction in systemic blood pressure In biomedical research isradipine is studied for its potential neuroprotective properties related to calcium-mediated excitotoxicity offering implications for conditions associated with neuronal calcium imbalance
Medchemexpress LLC Palbociclib impurity 20 | 1774898-55-3 | 99.9% | 308.34 | 50 MG
Palbociclib impurity 20 is an impurity of Palbociclib (HY-50767). This product is for research use only.
- Solid appearance
- Molecular weight 308.34
- Chemical formula C14H20N4O4
- Store powder at -20°C for 3 years, 4°C for 2 years
- Store in solvent at -80°C for 6 months, -20°C for 1 month